The role of key growth proteins in Changgaogao milk powder on children's growth

As a parent who is worried that the child is not nutritious enough, will not grow taller, or does not develop well, he will give his child calcium supplements. However, in addition to calcium, protein is also very important during the growth of the child, and even many key growth factors Protein can directly act on the reproduction of growth factor cells in the body, which has a positive effect on the growth and development of children. Which imported children's growth is better? Many parents choose Changgaogao milk powder for their children. One of the reasons is that the milk source is extracted from bovine colostrum. Why is Changgaogao milk powder extracted from bovine colostrum better for children's growth? The key is that it contains key growth proteins. What are the growth proteins mentioned in common milk powders on the market, and what are their corresponding auxiliary effects on growth? Today I will analyze the colostrum protein that everyone is familiar with.

1. Powerful colostrum

First of all, let's take a look at what colostrum is. Colostrum refers to the milk produced by cows within 72 hours after giving birth. It has high nutritional value. Bovine colostrum contains more than 250 active compounds, including immunoglobulins, lactoferrin, insulin-like growth factors (IGF-I and IGF-II), platelet-derived growth factor (PDGF), epidermal growth factors, and epidermal growth factors that are beneficial to the human body. Rich immune factors and growth factors such as factor (EGF) and transforming growth factor-β2 (TGF-β2) can stimulate the activity of corresponding immune and growth cells in the body and regulate cell growth and reproduction. For example, the epidermal growth factor in bovine colostrum can help the reproduction of normal skin cells and tissues, accelerate skin growth or wound repair, etc. Moreover, compared with ordinary milk, bovine colostrum is richer in vitamins and minerals, especially in children, which has a positive impact on strengthening the defense mechanism of children's bodies, improving the body's immunity, and resisting germs.

2. Types of colostrum proteins

-Lactoferrin

Children's growth milk powder containing lactoferrin

CowColostrum contains a variety of proteins, the first of which is lactoferrin mentioned above. Lactoferrin is a non-heme-binding glycoprotein and a member of the transferrin family. The concentration of lactoferrin in bovine colostrum is 0.34~1.96g/L, and the molecular weight is 80kDa. Lactoferrin has multiple functions. For example, it can promote the growth of beneficial intestinal bacteria such as Bifidobacteria, regulate intestinal flora imbalance, and can also show strong antibacterial activity against a variety of bacteria and fungi. In addition, lactoferrin has a strong affinity with iron ions, thereby increasing the absorption rate of iron and regulating the function of the immune system, but it does not have a great effect on regulating growth cells.

-Lactopontin

Children's growth milk powder containing lactoppontin

Colostrum also contains important protein, which is milk pontin LPN. Lactoponin LPN is an important immunoactive protein in breast milk. This protein was first found in bone tissue, so it is called osteopontin (OPN). With further research, it was discovered that OPN has two forms, one is secretory OPN, and the other is intracellular OPN. The secretory OPN derived from breast milk is called milk-derived osteopontin, which is now known as milk-derived osteopontin. pontin LPN.

Chart source: Jing Zhu, Xue Yu2, et al. Longitudinal changes of lactopontin (milk osteopontin) in term and preterm human milk, (2022)

According to relevant research results, there is a close relationship between LPN concentration levels and infant weight. Relevant studies have compared the concentration of LPN in breast milk samples of mothers with premature infants and super-premature infants at 7, 14, and 28 days postpartum. The results of the study showed that at 14 days postpartum, the LPN level in breast milk was significantly higher than that of full-term infants. The correlation analysis of the study found that the LPN concentration in breast milk was negatively correlated with the infant's weight 28 days postpartum, which confirmed that high LPN concentration levels in breast milk may contribute to the early catch-up growth of infants, that is, premature infants, etc. submitNowadays, newborns who are naturally disadvantaged need high concentrations of lactoponin to promote their growth and development.

-CBP

Children's growth milk powder containing colostrum alkaline protein

Finally, bovine colostrum also contains rare growth Protein - colostrum basic protein CBP. The molecular weight of CBP is 30kDa. It has a small molecular weight and is easier to absorb and digest. It can directly act on osteoblasts and help promote the proliferation of osteoblasts, thereby promoting bone growth and development and protecting bone health.

Chart source: Jeongrai Lee, Hyun-Mi Kim, et al., Effect of a Growth Protein-Colostrum Fraction on Bone Development in Juvenile Rats, Bioscience, Biotechnology, and Biochemistry(2008)

A related study conducted such an experiment: 25 rats were prepared for one week Three groups of experiments were conducted on 5-year-old experimental mice. One group of mice was not fed CBP as the control group, one group was fed 1% CBP, and the other group was fed 10% CBP. For this experiment, it should be noted that mouse osteoblast MC3T3-E1 is a type of pluripotent stem cell, a cell line widely used in osteoblast research, and can differentiate into osteoblasts under cell culture conditions. , cartilage cells, muscle cells and other cell types. During the bone formation process, osteoblasts undergo three processes: proliferation, extracellular matrix maturation, and extracellular matrix mineralization. By conducting experiments on mouse osteoblast MC3T3-E1, we can well observe the changes in osteoblasts. , which helps to study whether there is a close relationship between CBP and bones.

Chart source: Jeongrai Lee, Hyun-Mi Kim, et al., Effects of Colostrum Basic Protein from Colostrum Whey Protein: Increased in Osteoblast Proliferation and Bone Metabolism, J Food Sci Nutr (2007)

During the experiment, when When CBP reaches 100 µg per milliliter, the osteoblast proliferation effect is as high as 126.67%. Therefore, it can be inferred that CPB can effectively promote osteoblast proliferation, which also means that CBP helps promote collagen synthesis and bone growth and development. . In addition, the experimental results also showed that the bone weight of the 1% CBP group was 20% higher than that of the control group, and the bone weight of the 10% CBP group was 27% higher than that of the control group. It can be seen that taking in more CBP can help activate osteoblasts, increase bone weight and bone density, and play an important role in promoting bone growth and development.

Through the above large-scale research, I believe everyone has discovered important knowledge points. During the golden growth period of children, the role of protein is indispensable. Neglect, especially the key growth proteins in bovine colostrum, such as CBP and other growth proteins, which play an indispensable role in promoting the growth and development of children.

What kind of growth help should real growth milk powder bring to children? In addition to improving the child's overall immunity and helping the child better absorb nutrients, of course, more importantly, it contains ingredients that have a positive effect on the healthy development of the child's bones. CBP colostrum basic protein is a growth protein extracted from colostrum using freeze-drying technology. Different from other growth proteins, the molecules are smaller and easier to be absorbed in the child's body. It is precisely because CBP has very strict requirements on extraction technology that the investment cost is higher. Growth milk powders currently on the market, such as Changgaogao milk powder, contain organic colostrum basic protein (BIOCBP). Although the price is higher than other growth milk powders, they are truly made from Danish organic milk and contain European organic colostrum. Alkaline protein growth milk powder gives parents more peace of mind and is favored by more parents!

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